![]() ![]() ![]() Concurrently, formalin injection decreased antioxidative functions. Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) levels in serum and leukocyte migration in paws. Radon inhalation inhibited the second phase of response in formalin test. 19 Bq/m(3)), 1,000 or 2,000 Bq/m(3) for 24 h, 1.35 % formalin (0.5 % formaldehyde in saline, 20 μl) was subcutaneously injected into the hind paw of mice, and we measured licking response time. Immediately, after radon inhalation at a concentration of background level (ca. In this study, we investigated the antinociceptive effects of radon inhalation in a mouse model of formalin-induced inflammatory pain. The mechanisms of pain relief remain to be fully elucidated. Radon therapy is clinically useful for the treatment of inflammatory diseases. Yamato, Keiko Kataoka, Takahiro Nishiyama, Yuichi Taguchi, Takehito Yamaoka, Kiyonori Antinociceptive effects of radon inhalation on formalin-induced inflammatory pain in mice. ![]()
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